Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with …
W Albrecht, A Unger, SM Bauer, SA Laufer - 2017 - ACS Publications
The anti-inflammatory potential of p38 mitogen-activated protein kinase (MAPK) inhibitors
was coincidentally expanded to a dual inhibition of p38α MAPK and phosphodiesterase 4
(PDE4), and the potential benefits arising from the blockage of both inflammation-related
enzymes were thoroughly investigated. The most promising compound, CBS-3595 (1), was
successively evaluated in in vitro experiments as well as in ex vivo and in vivo preclinical
studies after administration of 1 to rodents, dogs, and monkeys. The resulting data clearly …
was coincidentally expanded to a dual inhibition of p38α MAPK and phosphodiesterase 4
(PDE4), and the potential benefits arising from the blockage of both inflammation-related
enzymes were thoroughly investigated. The most promising compound, CBS-3595 (1), was
successively evaluated in in vitro experiments as well as in ex vivo and in vivo preclinical
studies after administration of 1 to rodents, dogs, and monkeys. The resulting data clearly …
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